Needless to say (if you glanced at my icon), you'll pick up that I LOVED Sheldon and Penny. Understandably, Sheldon is my favorite character, but somewhere in there, Penny sneaked up to become my second favorite and I found that my favorite episodes were ones that highlighted the Penny/Sheldon dynamic -- "The Barbarian Sublimation" (Penny gets addicted to online gaming) and "The Panty Piñata Polarization" (Penny and Sheldon fight) were AWESOME!!! I know it's extremely, never-gonna-happen unlikely that anything romantic will happen between them -- I mean, it's SHELDON!, and it's SHELDON AND PENNY!!! -- but I enjoy all of their scenes so much, I'm just happy with whatever I get with them.
On the other hand, I'm kinda hoping that nothing WILL ever happen again with Leonard and Penny because they just don't work. Besides, I still kinda want something with Leonard and Leslie Winkle because ... come on! It's Darlene and David from Roseanne. I LOVED those two, so I love every scene with the two of them. On the other other hand, I've liked Sara Rue since I saw her in Less Than Perfect (even if I found I didn't like her character so much in Popular, which I watched after LTP) -- and I'm really glad she's gained some weight again because super-skinny Sara Rue was not as attractive as how she looked on LTP and on this show, so I'm cool with Leonard and Dr. Stephanie. But I still love Leonard and Leslie.
Or maybe I just love Leslie. That's possible, as I love Sara Gilbert. But aside from the Leonard/Lesie hook-ups that are amusing, the hate/hate relationship between Leslie and Sheldon is a riot also. Jim Parsons IS a magnificent find, and Kaley Cuoco is pretty good -- the fact that I say this despite the fact that she reminds me a tad of Jennifer Anniston says how good pretty good is, in my book. Johnny Galecki is enjoyable (although, it's funny watching him here as the nerd, when he was the cool "artist" on Roseanne). Simon Helberg (Howard) and Kunal Nayyar (Raj) are fun too. Ooh, and I LOVED that Laurie Metcalf (also formerly of Roseanne) plays Sheldon's mom.
Great cast overall, the dialogue cracks me up as a self-professed nerd/geek, pick your term. Other than the uber-science stuff, I recognize (and have participated in) much of their nerdy habits and it's awesome. So yeah, great show, I don't know why I waited so long to watch it. And now I have a companion to How I Met Your Mother on Monday nights. :D